Download Erythropoietin and the Nervous System by Ahmet Höke PDF

By Ahmet Höke

ISBN-10: 0387300104

ISBN-13: 9780387300108

Erythropoietin (EPO) is a chemokine hormone that's generally allotted during the physique. as well as its conventional function as a hormone that stimulates pink blood mobilephone construction, in recent times many laboratories have proven that EPO can act as a neuroprotective compound in quite a few damage paradigms within the worried procedure. previous event with rather safeguard profile of this FDA-approved drug makes it an amazing candidate to take it into medical trials for neuroprotection. we're at the verge of significant medical trials utilizing this drug for neuroprotection in illnesses starting from stroke, to transverse myelitis to chemotherapy-induced peripheral neuropathy. this is often the 1st publication of its style that brings jointly researchers from many alternative disciplines of neuroscience to study the present state of the art in EPO and the fearful method. This ebook will profit scientists and clinicians attracted to neuroprotection within the broadest sense.

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Erythropoietin and the Nervous System

Erythropoietin (EPO) is a chemokine hormone that's largely allotted during the physique. as well as its conventional function as a hormone that stimulates pink blood mobile construction, lately many laboratories have proven that EPO can act as a neuroprotective compound in quite a few harm paradigms within the frightened process.

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Manabe Y, Nagano I, Gazi MS, Murakami T, Shiote M, Shoji M, Kitagawa H, Abe K (2003) Glial cell line-derived neurotrophic factor protein prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis. Neurol Res 25:195-200. Marti HH, Bemaudin M, Petit E, Bauer C (2000) Neuroprotection and Angiogenesis: Dual Role of Erythropoietin in Brain Ischemia. News Physiol Sci 15:225-229. Marti HH, Wenger RH, Rivas LA, Straumann U, Digicaylioglu M, Henn V, Yonekawa Y, Bauer C, Gassmann M (1996) Erythropoietin gene expression in human, monkey and murine brain.

Risau W (1997) Mechanisms of angiogenesis. Nature 386:671-674. Ruscher K, Freyer D, Karsch M, Isaev N, Megow D, Sawitzki B, Priller J, Dimagl U, Meisel A (2002) Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J Neurosci 22:10291-10301. Sadamoto Y, Igase K, Sakanaka M, Sato K, Otsuka H, Sakaki S, Masuda S, Sasaki R (1998) Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery.

2002). Currently, a larger multi centre study is under way. 8. SUMMARY A primary goal, not only for stroke patients but also for other diseases of the CNS, is to protect neural function. Imitation of brain endogenous protective mechanisms may be the key to future successful approaches to neuroprotection; therefore activation and mimicry of endogenous mechanisms can be expected to be efficient and well tolerated (Ehrenreich 26 Chapter 2 and Siren, 2001b). In this respect, EPO may be a showpiece.

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