By David R. Brown
ISBN-10: 981436407X
ISBN-13: 9789814364072
This booklet describes the newest examine on neurodegenerative ailment and metal-binding proteins. It lays powerful emphasis on biochemistry and mobile biology. The ailments coated within the ebook contain Parkinson's affliction, Alzheimer's ailment, prion ailment, and ALS. The chapters individually learn such concerns as mechanisms of steel binding, metal-induced structural adjustments in proteins, changes in mobile steel metabolism in sickness, and makes an attempt at a healing method according to protein steel binding.
Read Online or Download Brain diseases and metalloproteins PDF
Best neurosurgery books
Musculoskeletal Diseases: Diagnostic Imaging and Interventional Techniques
This ebook represents a condensed model of the 20 subject matters facing imaging analysis and interventional cures in musculoskeletal illnesses. The disease-oriented themes surround all of the suitable imaging modalities together with X-rays expertise, nuclear medication, ultrasound and magnetic resonance, in addition to image-guided interventional thoughts.
Erythropoietin and the Nervous System
Erythropoietin (EPO) is a chemokine hormone that's greatly dispensed through the physique. as well as its conventional position as a hormone that stimulates purple blood mobile creation, lately many laboratories have proven that EPO can act as a neuroprotective compound in a number of harm paradigms within the fearful procedure.
Percutaneous Vertebroplasty is a concise and updated reference that info the necessities for establishing a latest medical lab, settling on sufferers, effectively acting the approach and averting pitfalls which are regularly encountered. Over ninety five pictures, in particular created for this booklet, give you the reader with precise examples of the way each one element of the process is played in an comprehensible step-by-step structure.
Electroceuticals: Advances in Electrostimulation Therapies
This e-book covers fresh advances within the use of electrostimulation treatments in circulate problems, epilepsy, inflammatory bowel ailment, reminiscence and cognition, problems of realization, foot drop, dysphagia, mind damage, headache, center failure, listening to loss, and rheumatoid arthritis. It describes innovations comparable to vagus nerve stimulation, deep mind stimulation, and electric stimulation of the pharyngeal nerve.
- Intracranial Vascular Malformations and Aneurysms From Diagnostic Work-Up to Endovascular Therapy
- Stereotactic Techniques in Clinical Neurosurgery
Extra info for Brain diseases and metalloproteins
Example text
Shepardson, N. , Brett, F. , Farrell, M. , Rowan, M. , Lemere, C. , Regan, C. , Walsh, D. , Sabatini, B. L. and Selkoe, D. J. (2008) Amyloid-β protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory. Nature Med. 14, pp. 837– 842. Sipe, J. D. and Cohen, A. S. (2000) Review: History of the amyloid fibril. J. Struct. Biol. 130, pp. 88–98. Smith, M. , Harris, P. L. , Sayre, L. M. and Perry, G. (1997) Iron accumulation in Alzheimer’s disease as a source of redox-generated free radicals.
Ashcroft, A. , Korchazhkina, O. V. and Exley, C. (2004) Metalmediated formation of fibrillar ABri amyloid. J. Inorg. Biochem. 98, pp. 2006–2010. , Ashcroft, A. , Korchazhkina, O. V. and Exley, C. (2005) Metals accelerate the formation and direct the structure of amyloid fibrils of NAC. J. Inorg. h 99, pp. 1920–1927. indd 28 6/20/2012 11:15:27 AM References 29 Kim, H. , Chae, S. , Lee, D. , Lee, S. , Park, Y. , Klein, W. , Krafft, G. , and Hong, S. T. (2003) Selective neuronal degeneration induced by soluble oligomeric amyloid β protein.
G. (2005) Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J. Biol. Chem. 280, pp. 17294–17300. Dobson, C. M. (1999) Protein misfolding, evolution and disease. Trends Biochem. Sci. 24, pp. 329–332. , Atwood, C. , Anderson, V. , Siedlak, S. , Smith, M. , Perry, G. and Carey, P. R. (2003) Metal binding and oxidation of amyloid-β within isolated senile plaque cores: Raman microscopic evidence. Biochemistry 42, pp. 2768–2773. , Allsop, D.