By David R. Brown
This booklet describes the newest examine on neurodegenerative ailment and metal-binding proteins. It lays powerful emphasis on biochemistry and mobile biology. The ailments coated within the ebook contain Parkinson's affliction, Alzheimer's ailment, prion ailment, and ALS. The chapters individually learn such concerns as mechanisms of steel binding, metal-induced structural adjustments in proteins, changes in mobile steel metabolism in sickness, and makes an attempt at a healing method according to protein steel binding.
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Extra info for Brain diseases and metalloproteins
Shepardson, N. , Brett, F. , Farrell, M. , Rowan, M. , Lemere, C. , Regan, C. , Walsh, D. , Sabatini, B. L. and Selkoe, D. J. (2008) Amyloid-β protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory. Nature Med. 14, pp. 837– 842. Sipe, J. D. and Cohen, A. S. (2000) Review: History of the amyloid fibril. J. Struct. Biol. 130, pp. 88–98. Smith, M. , Harris, P. L. , Sayre, L. M. and Perry, G. (1997) Iron accumulation in Alzheimer’s disease as a source of redox-generated free radicals.
Ashcroft, A. , Korchazhkina, O. V. and Exley, C. (2004) Metalmediated formation of fibrillar ABri amyloid. J. Inorg. Biochem. 98, pp. 2006–2010. , Ashcroft, A. , Korchazhkina, O. V. and Exley, C. (2005) Metals accelerate the formation and direct the structure of amyloid fibrils of NAC. J. Inorg. h 99, pp. 1920–1927. indd 28 6/20/2012 11:15:27 AM References 29 Kim, H. , Chae, S. , Lee, D. , Lee, S. , Park, Y. , Klein, W. , Kraﬀt, G. , and Hong, S. T. (2003) Selective neuronal degeneration induced by soluble oligomeric amyloid β protein.
G. (2005) Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J. Biol. Chem. 280, pp. 17294–17300. Dobson, C. M. (1999) Protein misfolding, evolution and disease. Trends Biochem. Sci. 24, pp. 329–332. , Atwood, C. , Anderson, V. , Siedlak, S. , Smith, M. , Perry, G. and Carey, P. R. (2003) Metal binding and oxidation of amyloid-β within isolated senile plaque cores: Raman microscopic evidence. Biochemistry 42, pp. 2768–2773. , Allsop, D.