By Curtis Klaassen
The so much relied on all-in-one assessment of the biomedical and environmental points of toxicology--NOW extra whole, up to date, and in complete color
A Doody's middle identify for 2015!
NEW to the 8th Edition
- FULL-COLOR layout to permit for a clearer interpretationof the elemental parts of toxicology featured in the course of the textual content
- EXPANDED tables, illustrations, and different visuals areupdated with cutting-edge criteria that makes thisedition much more present and proper
- DVD with snapshot financial institution good points all tables and illustrations from the textual content in presentation-ready layout
- NEW CHAPTERS comprise "Toxic results of Calories"and "Toxic results of Nanoparticles"
The world's prime and so much authoritative textbook on poisons has extra to provide students,toxicologists, and pharmacologists than ever sooner than. Now in complete colour, and carefully revised, the 8th variation of Casarett & Doull's TOXICOLOGY: the fundamental technological know-how of Poisons not just promises a accomplished assessment of the fundamental parts of toxicology, it deals the main up-to-date,revealing, and in-depth examine the systemic responses of poisonous substance to be had anywhere.
Combined with the newest considering by way of the field's premiere students plus good assurance of normal ideas, modes of motion, and chemical-specific toxicity, this landmark textual content maintains to set the normal for toxicology references.
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The main relied on all-in-one evaluate of the biomedical and environmental points of toxicology--NOW extra entire, updated, and in complete colorA Doody's middle name for 2015! NEW to the 8th variation FULL-COLOR layout to permit for a clearer interpretationof the fundamental elements of toxicology featured during the textual content increased tables, illustrations, and different visuals areupdated with cutting-edge criteria that makes thisedition much more present and suitable DVD with photograph financial institution positive factors all tables and illustrations from the textual content in presentation-ready layout NEW CHAPTERS contain "Toxic results of Calories"and "Toxic results of Nanoparticles"The world's major and so much authoritative textbook on poisons has extra to provide students,toxicologists, and pharmacologists than ever sooner than.
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Extra resources for Casarett and Doull's toxicology
For some materials, both effects can be demonstrated. For example, tetraethyl lead produces effects on skin at the site of absorption and then is transported systemically to produce its typical effects on the CNS and other organs. If the local effect is marked, there may also be indirect systemic effects. For example, kidney damage after a severe acid burn is an indirect systemic effect because the toxicant does not reach the kidney. Most chemicals that produce systemic toxicity do not cause a similar degree of toxicity in all organs; instead, they usually elicit their major toxicity in only one or two organs.
1999). Binding of certain organophos- Some toxic effects of chemicals are reversible, and others are irreversible. If a chemical produces pathological injury to a tissue, the ability of that tissue to regenerate largely determines whether the effect is reversible or irreversible. Thus, for a tissue such as liver, which has a high ability to regenerate, most injuries are reversible, whereas injury to the CNS is largely irreversible because differentiated cells of the CNS cannot divide and be replaced.
With the lowest dose (6 mg/kg), 1 percent of the animals die. A normally distributed sigmoid curve such as this one approaches a response of 0 percent as the dose is decreased and approaches 100 percent as the dose is increased; but—theoretically—it never passes through 0 and 100 percent. However, the minimally effective dose 19 of any chemical that evokes a stated all-or-none response is called the threshold dose even though it cannot be determined experimentally. The sigmoid curve has a relatively linear portion between 16 and 84 percent.