By Jose V. Castell, Maria Jose Gmez-Lechn
In Vitro tools in Pharmaceutical learn presents a finished consultant to laboratory innovations for comparing in vitro organ toxicity utilizing mobile types. step by step sensible how you can practice and interpret assays for drug metabolism and toxicity evaluate are supplied, in addition to a comparability of alternative suggestions to be had. it's a welcome boost to the literature at a time while curiosity is starting to be in mobile in vitro types for toxicology and pharmacology reports. Key gains* Meets the continued call for for info during this box* Compares In Vitro ideas with different equipment* Describes cell-culture tools used to enquire toxicity in cells derived from various organs* contains contributions by means of prime specialists within the box
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In Vitro equipment in Pharmaceutical learn offers a accomplished consultant to laboratory strategies for comparing in vitro organ toxicity utilizing mobile versions. step by step functional tips to practice and interpret assays for drug metabolism and toxicity review are supplied, in addition to a comparability of alternative options to be had.
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Extra resources for In Vitro Methods in Pharmaceutical Research
References . . . . . . . . . . . . . . . . . . . . . . . . . 50 50 50 51 51 51 I. I N T R O D U C T I O N A . I n v i t r o toxicology The techniques to grow animal and human cells and tissues on plastic surfaces or in suspension have contributed significantly to the development of biomedical science. Thus the term in vitro refers primarily to the handling of cells and tissues outside of the body under conditions which support their growth, differentiation, and stability.
In Vitro 9: 543-547. 12. Whittle, E. , Barratt, M. , Carter, J. , Basketter, D. A. and Chamberlain, M. (1995) The skin corrosivity potential of fatty acids: in vitro rat and human skin testing and QSAR studies. Toxicol. In Vitro 10: 95-100. 13. Barratt, M. D. (1995) Quantitative structure activity relationships for skin corrosivity of organic acids, bases and phenols. Toxicol. Lett. 75: 169-176. 14. Oliver, G. J. , Pemberton, M. A. and Rhodes, C. (1986) An in vitro skin corrosivity t e s t modifications and validation.
L. E. ) QSAR and Environmental Toxicology- II, pp. 207-220. D. Reidel Publishing, Dordrecht, The Netherlands. Basketter, D. , Roberts, D. , Cronin, M. and Scholes, E. W. (1992) The value of the local lymph node assay in quantitative structure activity investigations. Contact Dermatitis 27: 137142. , Botham, P. , Bruner, L. H. and Spielmann, H. (1995) The EC/HO international validation study on alternatives to the Draize eye irritation test. Toxicol. in Vitro 9: 871-929. Gordon, V. (1992) The scientific basis of the EYTEX system.