By Jerome Engel Jr, Timothy A. Pedley MD, Jean Aicardi MD FRCP, Marc A. Dichter MD PhD, Solomon Moshé MD, Emilio Perucca MD, Michael Trimble MD
ISBN-10: 0781757770
ISBN-13: 9780781757775
Written and edited by means of world-renowned gurus, this three-volume paintings is, to cite a reviewer, "the definitive textbook approximately seizures and epilepsy". This moment variation is punctiliously up-to-date and offers you an entire print and multimedia package deal: the three-volume set plus entry to an built-in content material web site. greater than three hundred chapters hide the spectrum of biology, body structure, and medical details, from molecular biology to public healthiness issues in constructing international locations. incorporated are distinct discussions of seizure forms and epilepsy syndromes; relationships among body structure and medical occasions; psychiatric and scientific comorbidity; stipulations that may be unsuitable for epilepsy; and an expanding diversity of pharmacologic, surgical, and substitute cures, together with vagus nerve stimulation and deep mind stimulation. This version describes many new antiepileptic medicinal drugs, significant advances in surgery, and cutting-edge neuroimaging, EEG, and different applied sciences for prognosis and seizure prediction. A better half site bargains immediate entry to the total, absolutely searchable textual content, plus a picture financial institution of extra figures, video pictures, and annual updates to chose chapters.
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Extra info for Epilepsy: A Comprehensive Textbook (3-volume set)
Example text
Many environmental and physiologic factors modulate the probability of seizure occurrence: Fever, sleep deprivation, alcohol withdrawal, highly specific triggers in reflex epilepsy, hormonal fluctuations, and even nonspecific stress in some susceptible individuals. It is unknown, however, how these perturbations translate into increased epileptic susceptibility at the cellular or molecular level. 5 seizure happened at a particular time, rather than a week before or a few minutes later. Changes that alter neuronal excitability or the potential for synchronous interactions among neurons are undoubtedly important but remain to be specified in detail.
4 findings observed in surgical and autopsy specimens of epileptogenic brain areas, never produced enduring interictal consequences, even subtle, for behavior, personality, and social functioning. FIGURE 2. Graph showing the effect of the corticofugal volley from a cortical epileptiform discharge, evoked by stimulating a forepaw nerve, on the negative (triangles) and positive (squares) components of the cuneate nucleus field potential. Maximal inhibition of the cuneate sensory response occurred about 60 msec after the cortical spike.
It is also important to underscore the importance of interactions between genetic predisposition and environmental factors in the manifestation of seizures and the particular expression of a given disorder. Lennox13 was among the first to postulate a continuum between idiopathic and symptomatic epilepsies. He suggested that the occurrence of epileptic seizures derives from the complex interrelation of genetic factors and brain disease (Fig. 4). In any given patient, the relative contribution of genetic or acquired pathologic factors determines whether the epilepsy takes the form of an idiopathic disorder or a symptomatic one.