By Bruce E. Pollock
ISBN-10: 3805581300
ISBN-13: 9783805581301
"Guiding Neurosurgery through proof" presents its readers with a succinct overview of up to date neurosurgical perform whilst evaluated by way of evidence-based drugs criteria. It starts off with an creation of the concept that and ideas of evidence-based drugs. the next chapters handle the subjects of mind tumor epidemiology, benign grownup mind tumors, pediatric neurosurgery, endovascular therapy of cerebrovascular problems, lumbar backbone surgical procedure, minimally invasive backbone surgical procedure, stereotactic radiosurgery, trauma, and the therapy of power soreness issues through neurostimulation. each one bankruptcy summarizes the to be had literature and grades it in accordance with the standard of the facts. moreover, this e-book highlights not just the usefulness of evidence-based medication in neurosurgical perform, but in addition its obstacles in regards to neurosurgical issues which are usually infrequent and as a result most unlikely to judge in randomized medical trials. Neurological surgeons and neurologists, either working towards physicians and citizens in education, will locate during this booklet beneficial information regarding the perform of the various neurosurgical subspecialties by way of evidence-based drugs criteria.
Read or Download Guiding Neurosurgery by Evidence (Progress in Neurological Surgery Vol 19) PDF
Similar neurosurgery books
Musculoskeletal Diseases: Diagnostic Imaging and Interventional Techniques
This publication represents a condensed model of the 20 issues facing imaging prognosis and interventional treatments in musculoskeletal illnesses. The disease-oriented themes surround all of the proper imaging modalities together with X-rays expertise, nuclear drugs, ultrasound and magnetic resonance, in addition to image-guided interventional options.
Erythropoietin and the Nervous System
Erythropoietin (EPO) is a chemokine hormone that's extensively dispensed during the physique. as well as its conventional function as a hormone that stimulates purple blood mobilephone construction, in recent times many laboratories have proven that EPO can act as a neuroprotective compound in quite a few damage paradigms within the apprehensive method.
Percutaneous Vertebroplasty is a concise and up to date reference that info the necessities for developing a contemporary medical lab, settling on sufferers, competently acting the technique and heading off pitfalls which are quite often encountered. Over ninety five photos, in particular created for this e-book, give you the reader with special examples of the way every one element of the strategy is played in an comprehensible step-by-step structure.
Electroceuticals: Advances in Electrostimulation Therapies
This e-book covers fresh advances within the use of electrostimulation remedies in circulation problems, epilepsy, inflammatory bowel affliction, reminiscence and cognition, issues of cognizance, foot drop, dysphagia, mind damage, headache, center failure, listening to loss, and rheumatoid arthritis. It describes thoughts comparable to vagus nerve stimulation, deep mind stimulation, and electric stimulation of the pharyngeal nerve.
- Brain-Computer Interfaces: Revolutionizing Human-Computer Interaction
- The Amygdaloid Nuclear Complex: Anatomic Study of the Human Amygdala
- Atlas of CSF cytology
- The Cranial Nerves: Anatomy Imaging Vascularisation
- Rare Diseases and Syndromes of the Spinal Cord
- Biopsy Diagnosis of Peripheral Neuropathy
Extra resources for Guiding Neurosurgery by Evidence (Progress in Neurological Surgery Vol 19)
Sample text
G. 30–50% reductions in undesirable endpoints). Once standard of care (SOC) is established by RCT, alternative treatments for the same disease are usually tested against SOC rather than natural history or placebo. g. e. those based on a coherent pathophysiologic rationale, those that have stood the test of time in accepted clinical practice, and those which have a basic science research foundation) [217]. As a result, clinical studies of additional or newer treatments are more likely to require megaRCTs to demonstrate improved outcomes, or to result in null studies in smaller RCTs, and thus are less likely to be published or to be recognized as at least equivalent therapies (when in fact they may be superior).
There is a major difference between strength of effect for an intervention and strength of evidence supporting the use of that intervention [55]. Indeed there are interventions where the magnitude of effect is so strong with lower methodology analysis that the effect is very unlikely to be accountable by bias, and where failure to act on an individual case level or strongly recommend at a clinical practice parameter level is probably inappropriate. The introduction of penicillin in the 1930s and 1940s is a classic example.
However, while excellent for studying therapeutic interventions, the RCT is a poor methodology for studying other epidemiological questions. Furthermore, there may be an inflection point where strength of effect should outweigh strength of methodology in assessing the level of evidence, or where the quality of a given study should lead it to carry more weight than a study of poor quality utilizing a less biased methodology. RCT design is a poor methodology for answering or exploring epidemiological questions of potential disease etiology, pathophysiologic causality, therapeutic side effects, or describing new diseases [211].