By Philip L. Gildenberg MD, PhD (auth.), Guido Nikkhah, Marcus Pinsker (eds.)
ISBN-10: 3709114810
ISBN-13: 9783709114810
ISBN-10: 3709114829
ISBN-13: 9783709114827
Since its creation approximately sixty years in the past, stereotactic and practical neurosurgery has developed right into a interesting and interdisciplinary pastime that mixes smooth neurosurgery, neurobiology, and neuroimaging with cutting edge diagnostic and therapy techniques. during this assortment, stated specialists from Europe and North and South the United States current their clinical and scientific adventure in stereotactic and sensible neurosurgery for circulate issues and mind tumors. The contributions current a variety from the beginnings of human stereotactic neurosurgery to the main smooth molecular and restorative techniques to regard illnesses of the human worried procedure. They truly display that the self-discipline remains to be younger and dynamic with replacement and infrequently competing suggestions whose assessment is underway. in addition they rfile that operative lesioning options resembling thalamotomies, even though nonetheless selected less than definite conditions, were succeeded via novel neuromodulation ideas comparable to deep mind stimulation within the nice majority of medical cases.
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Sample text
Neurosurgery 45:1375–1382 14. Carpenter MB, Carpenter CS (1951) Analysis of somatotropic relations of the corpus luysi in man and monkey; relation between the site of dyskinesia and distribution of lesions within the subthalamic nucleus. J Comp Neurol 95:349–370 15. Coenen VA, Gielen FL, Castro-Prado F, Abdel RA, Honey CR (2008) Noradrenergic modulation of subthalamic nucleus activity in human: metoprolol reduces spiking activity in microelectrode recordings during deep brain stimulation surgery for Parkinson’s disease.
3 The microelectrode recording system (Inomed, Teningen, Germany), a microdrive with five parallel trajectories Micro- and Macroelectrodes The scope of the micro/macroelectrode involves neurophysiologically refining the proposed target area. Various manual and automatic recording microdrive systems are The target refinement in DBS remains controversial with regard to different recommended surgical protocols of clinical testing as well as neuroimaging modalities using imagefusion and neurophysiological techniques [2, 26, 27, 31, 51, 65].
Detailed description is given concerning the multichannel MER systems nowadays available for DBS of the basal ganglia, especially of the STN, as a useful tool for target refinement. Furthermore, an overview is given of the historical aspects, spatial mapping of the STN by MER, and its impact for accuracy and precision in current functional stereotactic neurosurgery. The pros concerning target refinement by MER means on the one hand, and cons including increased bleeding risk, increased operation time, local or general anesthesia, and single versus multichannel microelectrode recording are discussed in detail.