By Michael L.J. Apuzzo, Charles Y. Liu, Daniel Sullivan
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Carpenter L, Friehs G, Price L: Cervical vagus nerve stimulation for treatment-resistant depression. Neurosurg Clin N Am 14:275–282, 2003. 19. Connecticut Lobotomy Committee: A cooperative clinical study of lobotomy. Res Publ Assoc Nerv Ment Dis 27:769–794; 1948. 20. Davey L: John Farquhar Fulton. Neurosurgery 43:185–187, 1998. 21. Delgado JM: Yale University Medical School Congressional Record No. 26, vol 118, February 24, 1974. 22. Ebert D, Speck O, Konig A, Berger M, Hennig J, Hohagen F: 1H-magnetic resonance spectroscopy in obsessive compulsive disorder: Evidence for neuronal loss in the cingulate gyrus and the right striatum.
Until recently, psychosurgical procedures have consisted mainly of procedures designed to either ablate neural tissue or to simulate ablation via electrical stimulation. The future of neuromodulation will undoubtedly involve many concepts of neurorestoration, which seeks to repair, regenerate or repopulate malfunctioning or injured neural elements. Research into stem cells, bioactive materials, gene therapy and associated vector delivery systems, and nanotechnology all show promise in the realm of neurorestoration.
VOLUME 59 | NUMBER 4 | OCTOBER 2006 | 731 HELLER ET AL. 11. Ben-Menachem E, Manon-Espaillat R, Ristanovic R, Wilder B, Stefan H, Mirza W, Tarver W, Wernicke J: Vagus nerve stimulation for treatment of partial seizures: A controlled study of effect on seizures. Epilepsia 35:616–626, 1994. 12. Benadhira R, Saba G, Samaan A, Dumortier G, Lipski H, Gastal D, Kalalou K, Verdon CM, Januel D: Transcranial magnetic stimulation for refractory depression. Am J Psychiatry 162:193, 2005. 13. Binder D, Iskandar B: Modern neurosurgery for psychiatric disorders.