By Shayne C. Gad
Acute toxicology checking out presents the 1st defensive line opposed to very likely risky chemical compounds. This publication is a whole and functional advisor to engaging in and examining all regulatory required and common acute toxicity checks. It offers distinctive protocols for the entire universal try out designs and reports their improvement and ambitions. Acute Toxicology trying out, moment Edition will curiosity not just employees within the pharmaceutical undefined, but in addition researchers and scholars in toxicology and public health.
* Over a hundred tables summarizing and examining results
* whole assurance of all significant try designs and their obstacles and advantages
* present prestige of other try out designs and types
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Extra info for Acute Toxicology Testing
Federal Hazardous Substances Act Regulations, CFR 150, 41. Dannenberg, A. , Moore, K. , Schofield, B. , Pula, P. , and Bassett, D. P. (1987). Two new in vitro methods for evaluating toxicity to skin (employing short-term organ culture). In Alternative Methods in Toxicology (A. M. ), Vol. 5, pp. 115-128. Liebert, New York. DeLeo, V. , Harber, L. , Kong, B. , and Salva, S. D. (1987). Surfactantinduced cutaneous primary irritancy: An in vitro model. In Alternative Methods in Toxicology (A. M. ), Vol.
The collars are utilized to prevent removal of wrappings and patches by the animals, while allowing the animals food and water ad libitum. The wrapping is removed at the end of the 24-hr exposure period. The test substance skin site is wiped to remove any test substance still remaining. When colored test substances (such as dyes) are used, it may be necessary to wash the test substance from the test site with an appropriate solvent or vehicle (one that is suitable for the substance being tested).
4. The four intact (flee of abrasion) sites of administration are assigned a code number: 1. Test substance 2. Negative control 3. Positive control 4. Vehicle control (if required) 5. The pattern of administration (illustrated in Fig. 6) makes certain that the test substance and controls are applied to each position at least once. 6. Each test or control substance is held in place with a 1 x 1-in. square 12-ply surgical gauze patch. The gauze patch is applied to the appropriate skin site and secured with 1-in.