By Trevor J. Franklin, George Alan Snow
ISBN-10: 0387225544
ISBN-13: 9780387225548
The topic is one among significant curiosity in simple microbiology and infectious illnesses and the ebook is a recognized vintage.
Read Online or Download Biochemistry and Molecular Biology of Antimicrobial Drug Action PDF
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Extra resources for Biochemistry and Molecular Biology of Antimicrobial Drug Action
Sample text
Thus although the dimerization of vancomycin may in principle facilitate its antibacterial action, the dimerizing potential is relatively weak and it is unclear whether the dimer is indeed a significant contributor to the antibiotic activity of vancomycin in vivo. 12), is strongly dimerized and this may be a factor in the highly potent antibacterial activity of this promising drug. 5 Penicillins, cephalosporins and other p"lactam antibiotics Penicillin was the first naturally occuning antibiotic to be used for the treatment of bacterial infections, and the story of its discovery and development is one of the most inspiring in the history of medicine.
This system carried out the entire biosynthesis of peptidoglycan, including the final stage of cross-linking. 4 Antibiotics tliat inhibit peptidoglycan biosynthesis tivation. Measurements show that the widely used P~ lactam antibiotics have just such characteristics, and this scheme goes far to explain their outstanding effectiveness. There is good reason to suppose that the inactivation mechanism is the same with cross-linking transpeptidases as with DD-carboxypeptidases. The nature of the end products of penicillin degradation depends on the enzyme involved.
All subseciuent reactions occurring while the intermediates are linked to undecaprenyl phosphate take place without release from the membrane. 6). The modified disaccharide known as lipid II is formed by a 1,4-p linkage with liberation of UDP The involvement of undecaprenyl phosphate is not unique to peptidoglycan biosynthesis. It is also concerned in the biosynthesis of the polysaccharide chain in the 0-antigen produced by Salmonella typhimuriurn and in the formation of the polysaccharide elements of the lipopolysaccharides of Gram-negative bacteria; in Gram-positive bacteria it fulfils a similar role in the biosynthesis of teichoic acid or polysaccharides of the wall.