Download Biological Concepts and Techniques in Toxicology: An by Jim E. Riviere PDF

By Jim E. Riviere

ISBN-10: 082472979X

ISBN-13: 9780824729790

ISBN-10: 1420018442

ISBN-13: 9781420018448

Highlighting the most recent advances in molecular biology, mathematical modeling, quantitative probability review, and biopharmaceutical improvement, this reference provides how present medical purposes and strategies influence and revolutionize mainstream toxicological learn. providing findings from disciplines that might effect the way forward for toxicology in future years together with proteomics, toxicogenomics, and metabonomics, this expertly conceived advisor explores toxicological problems with specific international curiosity, equivalent to toxicity of nanomaterials, army jet fuels, and genetically-modified meals.

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Toxicogenomics in predictive toxicology in drug development. Chem Biol 2004; 11:161–171. 22. Irwin RD, Boorman GA, Cunningham ML, Heinloth AN, Malarkey DE, Paules RS. Application of toxicogenomics to toxicology: basic concepts in the analysis of microarray data. Toxicol Pathol 2004; 32(suppl 1):72–83. 23. Waters M, Boorman G, Bushel P, et al. Systems toxicology and the chemic effects in biological systems (CEBS) knowledge base. EHP Toxicogenomics 2003; 111:15–28. 24. gov/nct/. 25. Hughes TR, Mao M, Jones AR, et al.

Environ Health Perspect 2002; 110:1047–1050. 19. Amin RP, Hamadeh HK, Bushel PR, Bennett L, Afshari CA, Paules RS. Genomic interrogation of mechanism(s) underlying cellular responses to toxicants. Toxicology 2002; 181–182:555–563. 22 Amin et al. 20. Gant TW. Application of toxicogenomics in drug development. Drug News Perspect 2003; 16:217–221. 21. Suter L, Babiss LE, Wheeldon EB. Toxicogenomics in predictive toxicology in drug development. Chem Biol 2004; 11:161–171. 22. Irwin RD, Boorman GA, Cunningham ML, Heinloth AN, Malarkey DE, Paules RS.

Isobaric Tag Reagents The recent development and commercialization of amine-reactive labeling reagents for multiplexed relative and absolute protein quantification called Isobaric Tag Reagents (iTRAQTM), along with ProQUANTTM software (Applied Biosystems), promises to be a realistic alternative to the limitations of 2-DE and cysteinerestricted labeling reagents like ICAT. The utility of the iTRAC approach has been demonstrated in a study where this quantitative methodology was to identify global protein expression changes in a set of isogenic yeast strains (54).

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