By Jan Aaseth, Guido Crisponi, Ole Anderson
ISBN-10: 0128030720
ISBN-13: 9780128030721
Chelation remedy within the remedy of steel Intoxication offers a realistic advisor to using chelation treatment, from its easy chemistry, to to be had chelating antidotes, and the appliance of chelating brokers. a number of metals have lengthy been recognized to be poisonous to people, and proceed to pose nice hassle to regard. those demanding situations pose specific difficulties in business settings, with lead smelting recognized to be linked to hemopoietic adjustments and paralyses, and the inhalation of mercury vapor in mercury mining being tremendous damaging to the imperative fearful system.
Clinical event has proven that acute and protracted human intoxications with a number metals might be handled successfully through management of chelating brokers. Chelation treatment within the remedy of steel Intoxication describes the chemical and organic rules of chelation within the therapy of those poisonous steel compounds, together with new chelators reminiscent of meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS).
provides all of the present findings at the strength for chelation as a remedy for steel intoxication
provides useful guidance for choosing the main acceptable chelating agent
contains assurance on radionuclide publicity and steel garage diseases
Describes the chemical and organic rules of chelation within the remedy of poisonous steel compounds
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Extra resources for Chelation Therapy in the Treatment of Metal Intoxication
Example text
Mammalian MT binds three Zn(II) ions in its beta domain and four in the alpha domain. In some MTs, mostly bacterial, histidine participates in zinc binding. By binding and releasing zinc, metallothioneins (MTs) may regulate zinc levels within the body. Based on MT affinity constants, a number of toxic metal ions including Hg2+, Ag+, Cu+, Cd2+, Pb2+, and Bi2+, should be able to displace Zn2+ from MT (Nath, Kambadur, Gulati, Paliwal, & Sharma, 1988). The free zinc, in turn, is a key element for the activation and binding of transcription factors, in particular the metal regulatory transcription factor 1 (MTF-1) and thereby the released zinc induces synthesis of more MT (Huang, Shaw, & Petering, 2004).
Favorable toxicity profile of chelating agent and its complexes; a. be as tolerable as possible for administration at doses as high as possible; b. no fetotoxicity, no teratogenicity; 7. good intestinal absorption, so that the drug can be orally administered, but: a. be available for both oral and parenteral administration; b. be soluble in water and physiological medium for parenteral administration; 8. good bioavailability properties; 9. easy excretion of the toxic metal ion in the complexed form, via kidneys or via bile; 10.
Acute or chronic effects of metal toxicity may be manifested in different organs, including respiratory, cardiovascular, renal, and central nervous systems. Metal accumulation and poisoning may also occur in the absence of environmental exposure, as, for example, in transfusional siderosis, for example, in the thalassemias. Therapeutic chelating agents compete for toxic metals with ligands essential for physiological function. Chelating agents possess high affinity for the metal to be removed, releasing the metal ions from vulnerable endogenous structures by forming a nontoxic chelate.