By U.A. Meyer, Jean-Michel Metry, Urs B. Meyer
This precious paintings comprehensively covers all problems with drug routine compliance. In 3 sections--Clinical Trials, sufferer administration, and destiny Aspects--it offers with a subject of discussion and curiosity.
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Additional info for Drug regimen compliance : issues in clinical trials and patient management
Mount Kisco, NY: Futura, 1976. 5. Sackett DL, Haynes RB, eds. Compliance with Therapeutic Regimens. Baltimore: Johns Hopkins University Press, 1976. 6. Haynes RB, Taylor DW, Sackett DL, eds. Compliance in Health Care. Baltimore: John Hopkins University Press, 1979. 7. Wood HF, Simpson R, Feinstein AR, Taranta A, Tursky E, Stollerman G. Rheumatic fever in children and adolescents: a long-term epidemiologic study of subsequent prophylaxis, streptococcal infections, and clinical sequelae. I. Description of the investigative techniques and of the population studied.
A dosing correlate for any of these would logically serve as the basis for designing confirmatory studies, which may include pharmacodynamic studies in animals if ethical considerations preclude controlled studies in humans. Some may dismiss this approach as a new form of ‘data dredging’, but this criticism ignores the fundamental property of all drugs, which is the dose- and time-dependence of their primary actions, and the time-dependence of counter-regulatory responses to those primary actions.
Effectiveness? Yes Yes 2. Question Compliance measurement with high sensitivity and specificity? * No Yes 3. Question Measurement of compliance representative for the entire treatment interval? * No Yes 4. Question Is feedback of the course of the disease on compliance possible? Yes No Yes 5. Question Is compliance influenced by therapy? No 6. Question Compliance dependent on prognostic factors: Are prognostic factors known? 4 A decision tree can be used to decide whether to include compliance data in statistical analysis ‘explanatory approach’) stands for the aim to find out whether and how a medicine works.