Download Genetic Response to Metals by Sarkar PDF

By Sarkar

ISBN-10: 0585400466

ISBN-13: 9780585400464

ISBN-10: 0824796152

ISBN-13: 9780824796150

"Based at the First foreign Symposium on Metals and Genetics held lately on the medical institution for in poor health young children in Toronto, Ontario, Canada. the one e-book of its style to target the results of metals on DNA. offers updated details on new advancements within the box and their wide-ranging implications. Discusses the molecular mechanisms of metal-induced mutagenicity and carcinogenicity."

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L. D. Kocsis, Roc. Natl. Acad. S c i . USA 89: 7978-7982 (1992). 35. A. T. R Bolsover, Nature367 745-750 (1994). 36. RW. S. Fay,Eur. J. Cell Biol. 51: 120-127 (1990). 37. M. Waybill, RV. Yelamarty, Y. Zhang, RC. F. -J. C. L. S. ,Y. Cheung, Am. Physiol. 261: E49-57 (1991). 38. RV. A. Miller,RC. S. L. Y. Cheung, J. Clin. Invest. 85: 1799-1809 (1990). 39. P. Nicotera, D. J. P. Jones andS. Orrenius, Proc. Natl. Acad. Sci. USA 86: 453-457 (1989). 40. S. Hechtenberg andD. Beyersmann, Biochem. 289: 757-760 (1993).

Ca2+, p b 2 + M. CONCLUSIONS AND PERSPECTIVES Thenuclearlevelsoffree Ca2+ and free Zn2+donotfollowthe cytoplasmicconcentrationsoftheseionspassivelybutarecontrolled differentially. the uptake ofCa2+ into nuclei is an active, ATP-stimulated process,and Ca2+ mobilizationfromnuclei is stimulated by inositol 174,5-trisphosphate and GTP. These controls allow a distinct regulation of intranuclear Ca2+ and Ca2+'calmodulin dependent nuclear functions. The uptake of Ca2+ into nuclei is inhibited by nanomolar concentrations of F@+, and probably by Hg2+, too.

Up to now, no mechanism for the stimulation of Zn2+ mobilizationin nuclei has been detected. , via the activation of metallothionein and heat shock protein [50] promotors. The observed induction of the early control genes c-fos, c-myc and c-jun by Cd2+ may be mediated by &+ 14 Hechtenberg and Beyersmann 100 0 200 300 500 400 Time (S) -12 -11 -10 -9 -8 -7 -6 Extranuclear free Cd2+ (log M) Figure 7. Effect of Cd2+ on nuclearCa2+ uptake. A. Time dependenceof inhibition by Cd2+. Nuclei were preincubated for10 min with l O n M free Cd2+, washed, and supplemented with200 nM free Ca2+ and 1 m M ATP at the times indicated.

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