By Robert Krieger
ISBN-10: 0123743672
ISBN-13: 9780123743671
The Handbook of Pesticide Toxicology is a finished, two-volume reference advisor to the homes, results, and legislation of insecticides that gives the newest and such a lot whole info to researchers investigating the environmental, agricultural, veterinary, and human-health affects of pesticide use. Written via overseas specialists from academia, govt, and the personal quarter, the guide of Pesticide Toxicology is an in-depth exam of severe matters with regards to the necessity for, use of, and nature of chemical compounds utilized in glossy pest administration. This up to date 3rd variation contains at the book's culture of serving because the definitive reference on pesticide toxicology and recognizies the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the 1st edition.
Feature: offers a finished examine all features of pesticide toxicology in a single reference paintings.
Benefit: Saves researchers time in fast gaining access to the very most up-to-date definitive information on toxicity of particular insecticides in preference to looking through hundreds of thousands of magazine articles.
Feature: transparent exposition of danger identity and dose reaction relationships in each one bankruptcy that includes pesticide brokers and actions
Benefit: Connects the experimental laboratory effects to real-life functions in human overall healthiness, animal well-being and the environment.
Feature: All significant periods of pesticide considered.
Benefit: presents relevance to a much wider number of researchers who're engaging in comparative paintings in insecticides or their healthiness impacts.
Feature: diversified routes of publicity severely evaluated.
Benefit: Connects the loop among publicity and destructive impacts to those that are discovering the impacts of insecticides on people or wildlife.
Read or Download Handbook of Pesticide Toxicology, Volumes 1-2 (3rd Edition) PDF
Similar toxicology books
In Vitro Methods in Pharmaceutical Research
In Vitro equipment in Pharmaceutical examine presents a entire consultant to laboratory recommendations for comparing in vitro organ toxicity utilizing mobile types. step by step useful the best way to practice and interpret assays for drug metabolism and toxicity review are supplied, besides a comparability of alternative ideas to be had.
Casarett and Doull's toxicology
The main relied on all-in-one assessment of the biomedical and environmental elements of toxicology--NOW extra entire, updated, and in complete colorA Doody's center identify for 2015! NEW to the 8th version FULL-COLOR layout to permit for a clearer interpretationof the elemental parts of toxicology featured through the textual content accelerated tables, illustrations, and different visuals areupdated with state of the art criteria that makes thisedition much more present and correct DVD with photo financial institution beneficial properties all tables and illustrations from the textual content in presentation-ready layout NEW CHAPTERS comprise "Toxic results of Calories"and "Toxic results of Nanoparticles"The world's best and such a lot authoritative textbook on poisons has extra to provide students,toxicologists, and pharmacologists than ever ahead of.
This e-book describes in attention-grabbing aspect the diversity of experiments backed via the U. S. govt within which human topics have been uncovered to radiation, usually with out their wisdom or consent. in response to a overview of thousands of heretofore unavailable or categorized files, this document tells a gripping tale of the complex dating among technology and the kingdom.
The IACUC administrator's guide to animal program management
The IACUC Administrator’s consultant to Animal software administration helps IACUC administrators who assist with constructing, coping with, and overseeing a application of animal care and animal use. It presents many strategies and probabilities for particular operational practices (e. g. , find out how to construct a well-functioning IACUC, what a practical protocol template seems like) to meet regulatory specifications.
- Nitrosamines and Related N-Nitroso Compounds. Chemistry and Biochemistry
- Metal-Carbon Bonds in Enzymes and Cofactors
- CNS Injuries Cellular Responses and Pharmacological Strategies Pharmacology & Toxicology
- Nitrosamines and Related N-Nitroso Compounds. Chemistry and Biochemistry
- Safety Evaluation of Certain Food Additives: Sixty-eighth Meeting of the Joint FAO WHO Expert Committee on Food Additives (WHO Food Additives Series)
Additional info for Handbook of Pesticide Toxicology, Volumes 1-2 (3rd Edition)
Example text
G. CO-induced asphyxi ation) depending on the time to effect (death). Similarly problematic is the counting of dead animals. g. 14 days). For example, rats exposed to NO2 acutely by inhalation die of either spasm of the larynx or edema of the lungs. Spasm of the larynx and lung edema have very obviously different mechanisms of action and as such are part of different dose and time responses. Therefore, they will distort the c t concept if lumped together. The biggest problem with the ED 50 and LD 50 studies is that for the most part they were and are not conducted under conditions of toxicodynamic and/or toxicokinetic steady state and, therefore, almost all studies measure not only toxicity, but toxicity and recovery at the same time.
This is of course impos sible because relative potency is an intrinsic property of a chemical. In fact, this illusion of dose-dependent relative potency arises as a result of a lack of experimental con trol of the kinetics of toxaphene, whereas that of dieldrin is controlled coincidentally by its long half-life. The lack of kinetic control is very frequently one of the “hidden” variables in toxicologic experiments. Similarly, a lack of control of absorption after dermal application of chemicals can be only partially controlled by standardizing dosing volumes.
Clearly recovery in the form of adaptation has taken place. Any further sub-chronic studies should have been conducted on a timescale no longer than 25 or per haps 30 days, if the population studied was no larger than that used by Hayes (1967b). 9 99 95 Neoplasms (%) Determination of the 90-Dose ED 50 or LD 50 In calculating the conventional 1-dose LD 50, no account is taken of time, although, of course, animals given a single dose do not respond to it simultaneously. The 90-dose ED 50 is managed in a similar way; the animals are held long enough after the last dose to be sure that all reactions have been counted.