By Michael J Derelanko; Mannfred A Hollinger (eds.)
ISBN-10: 0849303702
ISBN-13: 9780849303708
Laboratory animal administration / Joseph C. Siglin and William H. Baker -- Acute, subchronic, and persistent toxicology / Carol S. Auletta -- Dermal inflammation and sensitization / Kimberly L. Bonnette, sunrise D. Rodabaugh and Christopher W. Wilson -- Ocular toxicology / Brendan J. Dunn -- primary inhalation toxicology / Paul E. Newton -- utilized inhalation toxicology / Gary M. Hoffman -- primary neurotoxicology / Gene E. Schulze -- utilized neurotoxicology / Rosemary C. Mandella -- Immunotoxicology : basics of preclinical overview / Robert V. residence and Peter T. Thomas -- Renal toxicology : renal functionality parameters for grownup Fischer-344, Sprague-Dawley, and Wistar rats / William J. Powers, Jr. -- Reproductive toxicology / Donald J. Ecobichon -- Developmental toxicology / Karen M. MacKenzie and Richard M. Hoar -- Endocrine toxicology : male replica / Suresh C. Sikka and Rajesh ok. Naz -- Endocrine toxicology : the feminine reproductive method / Patricia B. Hoyer and Patrick J. Devine -- Genetic toxicology / Richard H.C. San ... [et al.] -- Carcinogenesis / Michael J. Derelanko -- Animal histopathology / John C. Peckham -- Animal scientific pathology / Barry S. Levine -- Metabolism and toxicokinetics of xenobiotics / Mohamed B. Abou-Donia, Eman M. Elmasry and Aqel W. Abu-Qare -- In vitro tools for the prediction of ocular and dermal toxicity / John W. Harbell and Rodger D. Curren -- Ecotoxicology / David J. Hoffman ... [et al.] -- steel toxicology / Akira Yasutake and Kimiko Hirayama -- Human scientific toxicology / Jill Dolgin -- possibility evaluate ; Regulatory toxicology within the usa : an summary / Michael J. Derelanko -- Regulatory toxicology : U.S. EPA/chemicals (TSCA) / Henry C. Fogle -- Regulatory toxicology : U.S. EPA/pesticides (FIFRA) / Jane E. Harris -- Regulatory toxicology : U.S. FDA/pharmaceuticals / William J. Powers, Jr. -- Regulatory toxicology : clinical units / Steven J. Hermansky -- Regulatory toxicology : purchaser items / Dennis J. Naas -- Regulatory toxicology : notification of recent elements within the ecu Union / Michael J. Derelanko -- Regulatory toxicology : notification of latest ingredients in Canada, Korea, Australia, and China / Henry C. Fogle -- Miscellaneous info of toxicological importance / Mannfred A. Hollinger and Michael J. Derelanko
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Extra info for Handbook of toxicology
Sample text
5. 12. 5 1–3 ml/day 2n = 40 See Chapters 2, 5, 11, 12, and 18 for more detailed information. Copyright © 2002 by Taylor & Francis 6. 13 Identification, Bleeding, Anesthesia, and Euthanasia Methods for Laboratory Mice Identification methods Ear tags Ear punch, notch Tail tatoo identification number Subcutaneously implanted transponder Bleeding methods Orbital sinus “Tail Nick” Via heart after euthanasia Anesthesia methods Ketamine/xylazine, methoxyflurane, barbiturates, pentobarbital (5 mg/100 g IP) Euthanasia methods Barbiturate overdose CO2 inhalation Cervical dislocation 7.
B. FASTING Like humans, animals are often fasted in preparation for blood collection. Generally, fasting periods of 18–24 hours may be safely utilized for most species. However, for mice, fasting periods of 18–24 hours may lead to severe debility, dehydration, and even death. Therefore, it is recommended that fasting periods of no longer than 4–6 hours be used for this species. SECTION 13. ANESTHESIA AND ANALGESIA* A. GENERAL CONSIDERATIONS As stated earlier, investigators using live animals must employ appropriate anesthetic, analgesic, and sedative agents when necessary to control pain and distress, unless use of such agents would interfere with the specific objectives of the research.
Copyright © 2002 by Taylor & Francis Although CO has been shown to induce unconsciousness in animals with minimal discernible discomfort, the many dangers associated with CO outweigh its routine use in most laboratory settings. Nonetheless, CO inhalation is an acceptable method for euthanasia of many species, including dogs and cats, provided that compressed CO is used and the following precautions are taken: • Personnel must be thoroughly instructed in the use of CO and its associated hazards and limitations.