By D T W Yew
ISBN-10: 1466583401
ISBN-13: 9781466583405
Read or Download Ketamine : use and abuse PDF
Similar toxicology books
In Vitro Methods in Pharmaceutical Research
In Vitro equipment in Pharmaceutical learn presents a finished consultant to laboratory thoughts for comparing in vitro organ toxicity utilizing mobile types. step by step useful tips to practice and interpret assays for drug metabolism and toxicity review are supplied, besides a comparability of alternative thoughts to be had.
Casarett and Doull's toxicology
The main relied on all-in-one evaluation of the biomedical and environmental elements of toxicology--NOW extra whole, up to date, and in complete colorA Doody's center name for 2015! NEW to the 8th variation FULL-COLOR layout to permit for a clearer interpretationof the elemental parts of toxicology featured in the course of the textual content multiplied tables, illustrations, and different visuals areupdated with state of the art criteria that makes thisedition much more present and suitable DVD with snapshot financial institution beneficial properties all tables and illustrations from the textual content in presentation-ready structure NEW CHAPTERS contain "Toxic results of Calories"and "Toxic results of Nanoparticles"The world's top and such a lot authoritative textbook on poisons has extra to supply students,toxicologists, and pharmacologists than ever ahead of.
This booklet describes in interesting aspect the diversity of experiments subsidized through the U. S. govt during which human matters have been uncovered to radiation, usually with no their wisdom or consent. according to a overview of millions of heretofore unavailable or labeled files, this file tells a gripping tale of the difficult courting among technology and the nation.
The IACUC administrator's guide to animal program management
The IACUC Administrator’s advisor to Animal software administration helps IACUC administrators who assist with constructing, handling, and overseeing a software of animal care and animal use. It offers many thoughts and probabilities for particular operational practices (e. g. , the way to construct a well-functioning IACUC, what a useful protocol template feels like) to fulfill regulatory necessities.
- Handbook on the Toxicology of Metals, Fourth Edition
- Handbook of Chemical Risk Assessment: Health Hazards to Humans, Plants, and Animals, Three Volume Set
- A Handbook of Bioanalysis and Drug Metabolism
- Botulinum Toxins in Clinical Aesthetic Practice, Second Edition
- History of Toxicology and Environmental Health : Toxicology in Antiquity II
Additional resources for Ketamine : use and abuse
Sample text
2011). However, ketamine is considered to be relatively safe and does not result in severe side effects when used at a low dose and within a short period. As an NMDA receptor antagonist, ketamine can trigger excessive glutamate release and subsequent cortical excitation, which may induce psychosis-like behavior and cognitive anomalies (Yu et al. 2012). Acute Chapter two: Clinical applications and side effects of ketamine 23 effects of ketamine administration are primarily linked to aberrant activation of the prefrontal cortex and limbic structures with elevated glutamate and dopamine levels, which can provoke dose-dependent positive and negative schizophrenia-like symptoms.
2% in the control group (Krupitsky et al. 2007). Similarly, Jovaisa et al. (2006) demonstrated attenuation of opiate withdrawal symptoms with ketamine, suggesting its potential use in treating drug addiction. 7 Others Ketamine has also been proven to exert anti-inflammatory effects. As an NMDA receptor antagonist, ketamine acts at different levels of the inflammatory response, playing a role in inflammatory cell recruitment, cytokine production, and inflammatory mediator regulation. The resultant effect of these interactions confers to ketamine an anti-proinflammatory effect by limiting exacerbation of systemic inflammation without affecting local healing processes (Loix et al.
2000. Cognitive, dissociative and psychotogenic effects of ketamine in recreational users on the night of drug use and 3 days later. Addiction 95:575–590. , and Laheri, V. 2008. Comparison of oral ketamine and oral midazolam as sedative agents in pediatric dentistry. J. Indian Soc. Pedod. Prev. Dent. 26:97–101. , and Dorandeu, F. 2012. Combinations of ketamine and atropine are neuroprotective and reduce neuroinflammation after a toxic status epilepticus in mice. Toxicol. Appl. Pharmacol. 259:195–209.