By Ted A. Loomis
ISBN-10: 0080535631
ISBN-13: 9780080535630
ISBN-10: 0124556256
ISBN-13: 9780124556256
Loomis's necessities of Toxicology is an introductory textual content at the technological know-how of destructive biologic results linked to exposures to chemical substances of all kinds. The scope of this booklet encompasses a dialogue of the foremost sorts of chemical substances concerned; the overall homes of chemical substances and biologic structures as they effect the incidence of hazardous biologic results; the tools used to illustrate those results; and the root for medical analysis and remedy of damaging results of chemical compounds on people. person examples are used to illustrate all of the ideas less than dialogue. this article is a useful source for toxicologists in addition to a entire creation to the subject for graduate and complex undergraduate scholars in toxicology and public overall healthiness. Key good points * The ''classic textbook'' in toxicology * thoroughly revised and up-to-date * contains either ideas and techniques * calls for minimum historical past in chemistry and biology
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Extra resources for Loomis's Essentials of Toxicology
Sample text
In this way the administration of a 44 Loomis's Essentials of Toxicology second drug could induce toxicity from the first drug; for example, the strongly bound sulfonamide drugs can induce hypoglycemic coma by replacing antidiabetic drugs which are bound to protein. Also, when patients who have received quinacrine (Atabrine) for the treatment of malaria are given primaquine, the primaquine displaces the quinacrine, which rapidly reaches toxic concentrations in the blood. Compounds that accumulate in the body because of repeated frequent ingestion as contaminants of food have occasionally caused insidious harm to sizable populations of humans.
The factors responsible for hypersensitivity of biologic systems to chemicals are an important part of the study of toxicology. RESPONSE CONCEPTS FOR COMPOUNDS ESSENTIAL TO THE BIOLOGIC SYSTEM Although the foregoing description of the direct relationship between the concentration of a chemical and any given response is correct for all 31 Numbers in Toxicology compounds that are not normally present in the biologic system (such compounds are frequently called "xenobiotics," taken from the word "xeno," meaning foreign or strange), the concept does not hold for compounds that are normally present in the biologic system (that is, normal endogenous compounds).
In the example given here, which is simplified for illustrative purposes, the LD50 is obtained from the curve by drawing a horizontal line from the 50% mortality point on the ordinate to where it intersects the curve. At the point of intersection, a vertical line is drawn and this line intersects the abscissa at the LD50 point. It is evident from the curve that information with respect to the lethal dose for 95% of the animals or for 5% of the animals also may be derived by a similar procedure.