Download Male-mediated Developmental Toxicity (Issues in Toxicology) by D. Anderson, M. Brinkworth PDF

By D. Anderson, M. Brinkworth

ISBN-10: 0854048472

ISBN-13: 9780854048472

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Extra info for Male-mediated Developmental Toxicity (Issues in Toxicology)

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9 Cancers in 11,380 parents of 5863 persons in whom cancer was diagnosed when they were under 15 years of age were documented by record linkage with the Danish Cancer Registry and compared with national incidence rates. The 11,380 parents were followed up for a diagnosis of cancer for 320,000 personyears, with follow-up starting on the date of birth of the child; on average, each parent was at risk of cancer for 28 years (range, 3 months to 47 years). 9 for fathers (Table 4). 7). Parents’ risk for cancer was not increased by having a child with any of the 10 major categories of the disease.

As we investigated cancer risk in the offspring of survivors, we were unable to address the potential mixture of familial cancers and cancers that might be due to transgenerational germ-cell mutations related to treatment of surviving parents. Nevertheless, the results of the study in offspring implied that fear that their offspring might develop cancer is no reason for the survivors of sporadic childhood cancer not to have children, and efforts to screen for cancer in the offspring of survivors of nonhereditary cancer in childhood or adolescence are not warranted.

18. W. Reik and J. Walter, Nat. Rev. , 2001, 2, 21–32. 19. H. Jiang, J. L. Beaudet, Annu. Rev. Genomics Hum. , 2004, 5, 479–510. 20. P. Feinberg and B. Tycko, Nat. Rev. Cancer, 2004, 4, 143–153. 21. D. Penny, Nature, 2005, 436, 183–184. 22. M. Balter, Science, 2005, 309, 234–237. Heritable Effects in Humans CHAPTER 2 Reproductive Outcomes among Men Treated for Cancer JOHN J. MULVIHILL AND TIMOTHY J. 1 Why Study Cancer Survivors? 1 One can assume half are male and hence estimate up to two million men in the US are cancer survivors with reproductive potential.

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