By Robert A. Goyer (Auth.)
ISBN-10: 0122943759
ISBN-13: 9780122943751
Metal Toxicology addresses the consequences of metals on human healthiness, in addition to their mechanisms of toxicity. not like so much books on steel toxicity that are equipped through person metals, this publication is prepared inan organ-by-organ foundation. It bargains with unifying mechanisms of steel toxicity inside a given tissue, and with publicity of a tissue to multiple steel at a time.
Unique point of organ-specific orientation
Written by way of major specialists in steel toxicology
Chapters of targeted curiosity comprise Risk evaluate, rising Technologies, and Molecular organic Techniques
Serves as a very good sourcebook of generalized info on steel toxicology, making an allowance for particular tissue-system referencing
Read or Download Metal Toxicology. Approaches and Methods PDF
Similar toxicology books
In Vitro Methods in Pharmaceutical Research
In Vitro equipment in Pharmaceutical study presents a entire consultant to laboratory concepts for comparing in vitro organ toxicity utilizing mobile types. step by step useful find out how to practice and interpret assays for drug metabolism and toxicity review are supplied, in addition to a comparability of alternative innovations on hand.
Casarett and Doull's toxicology
The main relied on all-in-one evaluation of the biomedical and environmental features of toxicology--NOW extra whole, updated, and in complete colorA Doody's center identify for 2015! NEW to the 8th version FULL-COLOR layout to permit for a clearer interpretationof the elemental parts of toxicology featured in the course of the textual content multiplied tables, illustrations, and different visuals areupdated with state of the art criteria that makes thisedition much more present and appropriate DVD with snapshot financial institution gains all tables and illustrations from the textual content in presentation-ready layout NEW CHAPTERS comprise "Toxic results of Calories"and "Toxic results of Nanoparticles"The world's best and so much authoritative textbook on poisons has extra to supply students,toxicologists, and pharmacologists than ever earlier than.
This publication describes in interesting aspect the range of experiments backed by means of the U. S. govt during which human matters have been uncovered to radiation, frequently with no their wisdom or consent. in accordance with a evaluate of millions of heretofore unavailable or categorized records, this record tells a gripping tale of the complex courting among technology and the nation.
The IACUC administrator's guide to animal program management
The IACUC Administrator’s consultant to Animal application administration helps IACUC administrators who assist with constructing, dealing with, and overseeing a software of animal care and animal use. It offers many strategies and probabilities for particular operational practices (e. g. , easy methods to construct a well-functioning IACUC, what a practical protocol template appears like) to meet regulatory necessities.
- Introduction to Food Toxicology
- Toxicology of Plant and Fungal Compounds (Handbook of Natural Toxins, Vol 6)
- Guardians of Science: Fairness and Reliability of Peer Review
- Environmental Contaminants in Biota: Interpreting Tissue Concentrations, Second Edition
Additional info for Metal Toxicology. Approaches and Methods
Sample text
Cadmium transport and toxicity in isolated perfused segments of the renal proximal tubule. Toxicol. Appi. Pharmacol. 121, 103-111. Sasser, L. , and Jarboe, G. E. (1977). Intestinal absorption and retention of cadmium in neonatal rats. Toxicol. Appi. Pharmacol. 4 1 , 4 2 3 - 4 3 1 . Scheuhammer, A. M. (1988). A dose-dependent deposition of cadmium into organs of Japanese quail following oral administration. Toxicol. Appi. Pharmacol. 9 5 , 1 5 3 - 1 6 1 . Shaikh, Z. , and Hirayama, K. (1979). Metallothionein in the extracellular fluids as an index of cadmium toxicity.
Lead-related interference with calcium ho meostasis and calcium messenger systems has been reviewed in detail by Pounds et al. (1991) and Bressler and Goldstein (1991). Intracellular calcium signals are received by a variety of calcium receptor proteins. The two that have received the most attention in relation to effects of lead are calmodulin and protein kinase C. Calmodulin serves as a sensor for the concentration of free calcium inside the nerve terminal, where it stimulates neurotransmitter release.
At least five transition metals or metalloids, in one form or another, are accepted as human carcinogens by the International Agency for Research on Cancer (IARC, 1973, 1976, 1980, 1987, 1990, 1993). Several more metals and/or their compounds are suspected to have carcinogenic potential in humans Metal Toxicology Copyright © 1995 by Academic Press, Inc. All rights of reproduction in any form reserved. 47 48 Michael P. Waalkes (IARC, 1973, 1976, 1980, 1987, 1990, 1993). Considering that the list of definitive human carcinogens is rather small (IARC, 1987), it is clear that metals, as a class, make up a substantial portion of the compounds known to have human carcinogenic potential.