By Dawna Armstrong, William Halliday, Cynthia Hawkings, Sachio Takashima
ISBN-10: 4431498982
ISBN-13: 9784431498988
ISBN-10: 4431702466
ISBN-13: 9784431702467
Neuropathology is the basis for figuring out developmental neuroscience, pediatric neurology, and neurosurgery, yet formerly a accomplished quantity masking all elements of pediatric neuropathology used to be now not on hand. This atlas is hence a special, finished reference supplying the basics of developmental mind issues of the worried approach which can have an effect on fetuses, babies and kids, in addition to the necessities of analysis in developmental mind pathology and neuroimaging. With an emphasis at the attribute morphology and a concise precis of medical positive aspects, pathogenesis, and genetics, the generously illustrated atlas provides greater than a hundred issues, together with the typical illnesses of the peripheral fearful approach in addition to genetically decided metabolic and garage illnesses. This compilation is a helpful source for pathologists, pediatric neurologists and neurosurgeons, geneticists, neonatologists, radiologists, and pediatricians.
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Extra resources for Pediatric Neuropathology: A Text-Atlas
Example text
Courtesy of K. ) Fig. 14-5. Fukuyama congenital muscular dystrophy. Microscopic section of fetal brain shows the irregular superficial cortical layer, which may exhibit polymicrogyria or lissencephaly in the mature brain. H&E. Fig. 14-6. Fukuyama congenital muscular dystrophy. MRI of the abnormal cortex shows an irregular intensity in the T2weighted image. 44 2. 15 Walker-Warburg Syndrome Walker-Warburg syndrome was described as a cerebroocular disorder exhibiting type 2 lissencephaly, hydrocephalus, and eye abnormalities.
Fig. 12-6. MRI of X-linked lissencephaly with abnormal genitalia (XLAG). There is a moderately thick cortex, more severe in the posterior brain than the anterior brain regions. Colpocephaly is present. (Courtesy of Dr. M. ) 38 2. 13 Hemimegalencephaly and Focal Cortical Dysplasia Hemimegalencephaly is associated with severe epilepsy, hemiplegia, and psychomotor delay. There are some associations with linear nevus, neurofibromatosis-1, tuberous sclerosis, and hemihypertrophy of the body. The brain exhibits hemimegalencephaly, and the cortex of the enlarged hemisphere exhibits regions with pachygyriapolymicrogyria and cortical dysplasia.
There is minimal fusion of the frontal lobes. Fig. 8-6. 8-4. H&E. 30 2. 9 Callosal Agenesis (Synonym: Agenesis of Corpus Callosum) With agenesis of the corpus callosum (ACC) there are complete (total) and incomplete (partial) types. Complete ACC: The entire corpus callosum is defective and its longitudinal fibers form the laterally situated Probst bundle, which contains the anteroposterior association axons. Incomplete ACC: The splenium is defective, and the genu remains wholly or partially intact.