Download Safety Evaluation of Certain Food Additives: Sixty-eighth by WHO PDF

By WHO

ISBN-10: 9240682856

ISBN-13: 9789240682856

ISBN-10: 9241660597

ISBN-13: 9789241660594

This quantity comprises monographs ready on the sixty-eighth assembly of the Joint FAO/WHO professional Committee on nutrition ingredients (JECFA), which met in Geneva Switzerland from 19 to twenty-eight June 2007. The toxicological monographs during this quantity summarize the security info on a few nutrition ingredients: acidified sodium chlorite asparaginase from Aspergillus oryzae expressed in Aspergillus oryzae carrageenan and processed Euchema seaweed cyclotetraglucose and cyclotetraglucose syrup isoamylase from Pseudomonas amyloderamosa magnesium sulfate phospholipase A1 from Fusarium venenatum expressed in Aspergillus oryzae sodium iron(III) ethylenediaminetetraacetic acid (EDTA) and steviol glycosides. Monographs on 8 teams of comparable flavouring brokers evaluated through the technique for the security overview of Flavouring brokers also are incorporated. This quantity additionally comprises monographs summarizing the toxicological and consumption information for the contaminants aflatoxins and ochratoxin A. This quantity and others within the WHO nutrients ingredients sequence comprise info that's invaluable to those that produce and use nutrition ingredients and veterinary medicines and people concerned with controlling contaminants in meals govt and meals regulatory officials business checking out laboratories toxicological laboratories and universities.

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Extra info for Safety Evaluation of Certain Food Additives: Sixty-eighth Meeting of the Joint FAO WHO Expert Committee on Food Additives (WHO Food Additives Series)

Sample text

During GD 7–11, there was a significant dose-related decrease in food consumption in the 600 mg/l and 1200 mg/ l groups and an associated decrease in body weight in the 1200 mg/l group, but no statistically significant changes in absolute body weights throughout the study. No treatment-related abnormalities were observed at maternal necropsy, and the mean number of corpora lutea, implantations, preimplantation losses and live fetuses and sex distribution were similar in all groups. The 600 and 1200 mg/l groups showed an increase in minor skeletal abnormalities and skeletal variants related to incomplete ossification of the pubis and sternebrae.

These changes were considered by the authors to be related to body weight. In the high-dose group, significant decreases in red blood cells, haemoglobin, haematocrit, mean corpuscular volume, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration were observed for all animals; in the 70 mg/l group, white blood cell count was significantly reduced. A statistically significant decrease in maximum startle response was seen in the 70 and 300 mg/l dose group pups on day 24 following birth, but the authors concluded that this was due to habituation of the control groups rather than any treatment-related effect.

No treatment- ACIDIFIED SODIUM CHLORITE 31 related effects were observed in the thyroid or other tissues (National Toxicology Program, 2005). 0 g/l in the drinking-water for 105 days, equivalent to about 0, 50, 100, 200, 400 and 600 mg/kg bw per day expressed as chlorate. , 2001). 0 g/l in the drinking-water for 21 days. The average doses were equivalent to 0, 20, 35, 75, 170 and 300 mg/ kg bw per day for males and 0, 20, 40, 75, 150 and 340 mg/kg bw per day for females (0, 16, 27, 59, 133 and 234 mg chlorate/kg bw per day and 0, 16, 31, 59, 117 and 265 mg chlorate/kg bw per day, respectively).

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