By Richard C. Stillman
ISBN-10: 0080219381
ISBN-13: 9780080219387
Papers of a convention held in Bethesda, MD, Dec. 21-22, 1976, and backed through the department of Reserach of the Natinoal Institute on Drug Abuse
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Extra resources for The Psychopharmacology of Hallucinogens
Sample text
A plot of the observed versus predicted molar ratios based on Eq. 4 is shown in Fig. 4. Other significant positive correlations were obtained with the frontier densities: f 4 (Eq. 5,8), f 3 (Eq. 6,9), and combinations of f 3 and f5 (Eq. 7, 10-12). In all cases, the major deviation from the regressions was found with 5,6-(0H)2 tryptamine, and elimination of this compound resulted in Equations 8-10. An examination of the residuals from Equations 4,8, and 9 and elimination of major deviant from each equation produced only a marginal improvement in the correlation.
Br. J . Pharmac. 53, 422 (1975). N. Synthetic a t r o p i n e - l i k e substances. S. Dept. Comm. ) (1962). R. Relationships between chemical structure and biological a c t i v i t y of convulsants. Ann. Rev. Pharmacol. 14, 9 (1974). R. The molecular structure of acetylcholine and adrenergic receptors: an a l l protein model. I n t e r n . Rev. Neurobiol. 17, 132 (1975). Smythies, J . R . D. On the molecular structure of receptors f o r co-carcinogens and some anti-cancer drugs. Psychoneuroendocrinology.
Thus, the correlation of biological activity with f-\, f3, fy, and f5 does not necessarily imply that any of these atoms is separately involved in the interactions with the receptor. A plausible alternative explanation is that high frontier electron density at all these sites is necessary for optimal activity. e. 5-HT, has high electron density at atoms N-l, C-3, C-4 and C-5; therefore the correlation indicates that the frontier density distribution in 5-HT is the most favorable for activity. This is also reflected in the fact that molecules with an oxygen substituent at the 5-position are clustered, all showing high biological activities compared LSD Receptor 45 with other derivatives (Table 1 ) .