Download Toxicology science of poisons by Curtis Klaassen PDF

By Curtis Klaassen

ISBN-10: 0071124535

ISBN-13: 9780071124539

ISBN-10: 0071347216

ISBN-13: 9780071347211

The so much relied on all-in-one assessment of the biomedical and environmental facets of toxicology--NOW extra entire, up to date, and in complete color

A Doody's center name for 2015!

NEW to the 8th Edition

  • FULL-COLOR layout to permit for a clearer interpretationof the fundamental elements of toxicology featured in the course of the textual content
  • EXPANDED tables, illustrations, and different visuals areupdated with cutting-edge criteria that makes thisedition much more present and suitable
  • DVD with photo financial institution gains all tables and illustrations from the textual content in presentation-ready layout
  • NEW CHAPTERS contain "Toxic results of Calories"and "Toxic results of Nanoparticles"

The world's major and so much authoritative textbook on poisons has extra to provide students,toxicologists, and pharmacologists than ever ahead of. Now in complete colour, and punctiliously revised, the 8th version of Casarett & Doull's TOXICOLOGY: the elemental technological know-how of Poisons not just offers a complete assessment of the fundamental parts of toxicology, it deals the main up-to-date,revealing, and in-depth examine the systemic responses of poisonous substance on hand anywhere.

Combined with the most recent pondering by means of the field's leading students plus sturdy assurance of basic rules, modes of motion, and chemical-specific toxicity, this landmark textual content keeps to set the traditional for toxicology references.

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Extra info for Toxicology science of poisons

Sample text

For example, mice are highly resistant to the hepatocarcinogenic effects of the fungal toxin aflatoxin B1. , 1974). com 2996R_ch02_023-028 26 4/11/01 9:38 AM Page 26 UNIT 1 GENERAL PRINCIPLES OF TOXICOLOGY suppressor gene (the Rb gene) (Wiman, 1993). Individuals with one mutated copy of the Rb gene and one normal copy are not destined to acquire the disease (as are those with two copies of the mutated gene), although their chance of acquiring it is much greater than that of persons with two normal Rb genes.

As our understanding of the human genome increases, more “susceptibility” genes will be discovered, and it is likely that the etiology of many chronic diseases will be shown to be related to a combination of genetics and environment. Simple blood tests may ultimately be developed that allow an individual to learn whether he or she may be particularly susceptible to specific drugs or environmental pollutants. Although the public health significance of this type of information could be immense, the disclosure of such information raises many important ethical and legal issues that must be addressed before wide use of such tests.

However, the use of the median effective and median lethal doses is not without disadvantages, because median doses tell nothing about the slopes of the dose–response curves for therapeutic and toxic effects. Margins of Safety and Exposure One way to overcome this deficiency is to use the ED99 for the desired effect and the LD1 for the undesired effect. These parameters are used in the calculation of the margin of safety: Margin of safety ϭ LD1/ED99 The quantitative comparisons described above have been used mainly after a single administration of chemicals.

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