By Joseph D. Roder, D.V.M., Ph.D., D.A.B.V.T. (Auth.)
ISBN-10: 0750672404
ISBN-13: 9780750672405
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Additional resources for Veterinary Toxicology
Sample text
Poison hemlock (Conium maculatum) • Skunk cabbage (Veratrum californicum); consumption by ewe on day 14 of gestation causes cyclopia in the lamb • Sorghum • Therapeutic agents • prednisone • vitamin A • Tobacco (Nicotiana tabacum) Common Veterinary Toxins Affecting the Skin Photosensitization Syndromes in Veterinary Medicine PRIMARY PHOTOSENSITIZATION • Plants • toxin: furocoumarin Umbelliferae family: celery, parsnip, parsley bishop’s flower (Ammi majus) Dutchman’s breeches (Dicentra cucullaria) 38 Clinical Presentation and Diagnosis of Common Veterinary Toxicants • toxin: hypericin St.
The cell membrane is an effective barrier that maintains ionic homeostasis. The concentrations of sodium and calcium are higher outside the cell membrane, and concentration of potassium is higher inside the cell. The nucleus is sending messenger RNA to the rough endoplasmic reticulum to produce proteins. The mitochondria are compact and produce ATP to fuel protein synthesis and the ATPases responsible for maintaining the ionic gradients. Figure 3–6 Dysfunctional and dying cell. This hypothetical cell has been exposed to a toxin.
If a free radical interacts with another free radical, an inert species is produced that is no longer reactive. RESULTS OF FREE RADICAL PRODUCTION • Lipid peroxidation of membranes • Cleavage of DNA • Destruction of enzymes or enzyme systems 62 Pathophysiology of Selected Mechanisms ENDOGENOUS FREE RADICAL SCAVENGERS • Glutathione • Superoxide dismutase • Catalase TOXINS THAT GENERATE FREE RADICALS See Figures 3–8 through 3–14. Figure 3–8 Pathway of generation of a superoxide anion. Figure 3–9 The Haber-Weiss pathway for production of hydroxyl radicals.