By C. Gad Shayne
ISBN-10: 0824754077
ISBN-13: 9780824754075
Reflecting greater than a decade’s worthy of alterations, Animal types in Toxicology, moment variation is a realistic advisor to the typical statistical difficulties encountered in toxicology and the methodologies which are to be had to resolve them. The ebook offers a historic evaluate of using animal types and an outline of huge concerns of metabolism and relevance utilized in toxicology. person chapters protecting the 8 significant species utilized in toxicology and experimental biology shape the center of the e-book. With contributions from specialists in toxicology, toxicological pathology, and species-specific metabolism, each one of those chapters supply a superb introductory “course” in addition to suggestions to the literature for extra special figuring out. The e-book is going directly to make the case for various species now not known for defense evaluation reviews yet that could supply helpful replacement versions for a few particular endpoints. The bankruptcy authors talk about certain issues relating to theevaluation and interpretation of the scientific pathology of the 8 significant version species in addition to find out how to pick out a version species and the way to extrapolate the implications to people. They aspect power pitfalls and events that reason both human or version to be considerably extra delicate than the opposite or completely beside the point to one another. The ebook concludes with an summary of the more and more advanced legislation and rules that govern how laboratory animals are got, maintained, and applied, and an appendix that offers a short advisor to advertisement resources of laboratory animals.
Read or Download Animal Models in Toxicology 2nd Edition (Drug and Chemical Toxicology) PDF
Best toxicology books
In Vitro Methods in Pharmaceutical Research
In Vitro tools in Pharmaceutical examine presents a entire advisor to laboratory options for comparing in vitro organ toxicity utilizing mobile versions. step by step sensible the right way to practice and interpret assays for drug metabolism and toxicity review are supplied, besides a comparability of alternative concepts on hand.
Casarett and Doull's toxicology
The main relied on all-in-one evaluate of the biomedical and environmental features of toxicology--NOW extra entire, updated, and in complete colorA Doody's center identify for 2015! NEW to the 8th version FULL-COLOR layout to permit for a clearer interpretationof the fundamental elements of toxicology featured in the course of the textual content elevated tables, illustrations, and different visuals areupdated with cutting-edge criteria that makes thisedition much more present and correct DVD with photograph financial institution positive aspects all tables and illustrations from the textual content in presentation-ready layout NEW CHAPTERS comprise "Toxic results of Calories"and "Toxic results of Nanoparticles"The world's major and such a lot authoritative textbook on poisons has extra to supply students,toxicologists, and pharmacologists than ever earlier than.
This publication describes in attention-grabbing element the diversity of experiments subsidized through the U. S. executive within which human topics have been uncovered to radiation, frequently with no their wisdom or consent. in response to a assessment of millions of heretofore unavailable or categorised records, this document tells a gripping tale of the tricky dating among technological know-how and the kingdom.
The IACUC administrator's guide to animal program management
The IACUC Administrator’s consultant to Animal application administration helps IACUC administrators who assist with constructing, coping with, and overseeing a software of animal care and animal use. It presents many suggestions and percentages for particular operational practices (e. g. , find out how to construct a well-functioning IACUC, what a practical protocol template seems like) to meet regulatory specifications.
- Thorium–232 and Uranium–238. The Toxicology of Radioactive Substances
- Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification
- Handbook of poisonous and injurious plants
- Advances in Isotope Methods for the Analysis of Trace Elements in Man (Modern Nutrition)
- A Handbook of Bioanalysis and Drug Metabolism
Extra info for Animal Models in Toxicology 2nd Edition (Drug and Chemical Toxicology)
Example text
6, 941–949. , and Ohmori, S. (1986). Comparison of glutathione S-transferase in mouse, guinea pig, rabbit, and hamster liver cytosol to those in rat liver. Biochem. Int. 13, 641–618. , and Taylor, I. (1982). Elimination of glyceryl trinitrate: Effects of sex age, species and route of administration, Br. J. Pharmacol. 77, 83–88. , and Ramasway, S. (1984). Sulfotransferases active with xenobiotics—Comments on mechanism. In Progress in drug metabolism, Vol. 8, eds. J. Bridges and L. Chasseaud, 11–33.
Biliary excretion of drugs and other xenobiotics. Ann. Rev. Pharmacol. Toxicol. 18, 81–96. Levy, R. , Thummel, K. , Tragen, W. , Hanslen, P. , and Eichelbaum, M. (2000). Metabolic drug interactions. Philadelphia: Lippincott, Williams & Wilkins. Lewis, D. F. V. (2001). Guide to cytochrome P450. Philadelphia: Taylor & Francis. , and Bryan, G. (1973). Enzymatic N-acetylation of carcinogenic aromatic amines by liver cytosol of species displaying different oran susceptibilities. Biochem. Pharmacol. 22, 1581–1588.
8, eds. J. Bridges and L. Chasseaud, 11–33. London: Taylor & Francis. , and Bend, J. (1977). Glutathione S-transferases. In Biological reactive intermediates: Formation, toxicity and inactivation, eds. D. Jallow, J. Kocsis, R. Snyder, and H. Vanio, 207–236. New York: Plenum. , and Hammons, G. (1987). The role of cytochrome P-450 in the metabolism of chemical carcinogens. In Mammalian cytochrome P450, Vol. 1, ed. F. Guengerich, 1–54. Boca Raton, FL: CRC Press. Kato, R. (1979). Characteristics and differences in the hepatic mixed function oxidases of different species Pharmacol.