By Donald Mattison
ISBN-10: 0123860075
ISBN-13: 9780123860071
Clinical Pharmacology in the course of Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and different doctors without delay interested in the care of girls while pregnant. This e-book makes a speciality of the effect of being pregnant on drug disposition and likewise contains insurance of remedies for ailments of particular physique platforms in addition to crucial content material on dosing and efficacy.
The huge diversity of this ebook encompasses analgesics, antiasthmatics, antidepressants, middle and circulatory medicines, supplements and natural supplementations, and extra. themes in chemotherapy and substance abuse are coated, as are study concerns, together with scientific trial layout and moral considerations.
- Uses an evidence-based technique for therapeutics in the course of pregnancy
- Includes a precis of particular medicinal drugs through indication with updated details on dosing and efficacy in being pregnant for the given indication
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Additional info for Clinical Pharmacology During Pregnancy
Sample text
54] Shanson DC, McNabb R, Hijipieris P. The effect of probenecid on serum amoxicillin concentrations up to 18 hours after a single 3 g oral dose of amoxicillin: possible implications for preventing endocarditis. J Antimicrob Chemother 1984;13:629–32. [55] Daniel H, Kottra G. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflueg Arch Eur J Physiol 2004;447:610–8. [56] Li M, Anderson GD, Phillips BR, Kong W, Shen DD, Wang J. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters.
G. g. meperidine, propranolol, digoxin) are known to have large volumes of distribution (1–10 L/kg). The volume of distribution for a drug affects the difference between peak and trough concentrations at steady state or maximum concentrations for single intravenous bolus dosing. The volume of distribution can be used to determine the loading dose needed to achieve a certain concentration. There are many physiologic changes that occur during pregnancy that can result in altered volume of distribution for medications.
Only about 1–3% of the maternal dose is excreted into milk [29]. These infants will still require very close observation in the hospital and after discharge to monitor possible withdrawal symptoms. 10 Resumption of pre-pregnancy medications With the possible exception of psychotropic drugs, almost all medications for acute and chronic maternal conditions are safe 4 Medications and the Breastfeeding Mother Hydrocodone is metabolized to the more active metabolite hydromorphone and both are excreted into breast milk.