By Robert S. Hoffman, Lewis S. Nelson, Mary Ann Howland, Neal A. Lewin, Neal E. Flomenbaum, Lewis R. Goldfrank
ISBN-10: 007144310X
ISBN-13: 9780071443104
Concise, "at the bedside" instructions for toxicologic emergencies--derived from the optimum reference within the box A Doody's middle name crucial buy! four celebrity DOODY'S evaluation! "This handbook is for prepared use at a patient's bedside or for an summary of clinical toxicology for housestaff, medical/pharmacy/nursing scholars, and different people who don't have the in-depth remedy or references/citations provided through the most textual content. this can be greater than a bedside relief -- it includes a wealth of knowledge at the present perform of scientific toxicology. Wonderful!" -- Doody's overview provider This sensible and transportable bedside guide is condensed for fast program from the masterwork looked for 1 / 4 of a century because the "gold ordinary" reference within the box of emergency toxicology: Goldfrank's Toxicologic Emergencies. you will discover depended on info at the medical rules that designate how pollutants have an effect on important symptoms, neurotransmitters, metabolic procedures, and organs and structures during the physique. Covers the total diversity of poisons contains prescribed drugs, leisure medications, and components of abuse; meals and plant pollutants; envenomations; family pollution; insecticides and herbicides; rodenticides; metals; poison gases; and environmental pollution Systematically reports toxicokinetics, pathophysiology, scientific manifestations, diagnostic checking out, and administration for every toxin offers "Antidotes in Brief"--at-a-glance publications to express antidotes and their basic purposes Authoritative answers--at your fingertips the right way to deal with the poisoned or overdosed sufferer What strategies successfully cast off pollution Which imaging modalities yield the easiest effects extra (20081119)
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Additional resources for Goldfrank's Manual of Toxicologic Emergencies
Example text
Instead, these therapies should be considered for all patients with altered mental status, unless specifically contraindicated. The physical examination should be used to guide the use of naloxone. Although CNS depression, miosis, and respiratory depression are characteristic, existing data suggests that respiratory depression (defined as a respiratory rate of ≤12 breaths/min) is the best predictor of response. If dextrose or naloxone is indicated, sufficient amounts should be administered to exclude and/or treat hypoglycemia or opioid toxicity, respectively.
Mofenson and Greensher coined the term toxidrome from the words toxic syndrome to describe the groups of signs and symptoms that consistently result from particular toxins. These syndromes are usually best described by a combination of the vital signs and clinically obvious end-organ manifestations. The signs that prove most clinically useful are those involving the central nervous system (mental status); ophthalmic system (pupil size); gastrointestinal system (peristalsis); dermatologic system: skin (dryness vs.
Infarction represents the loss of electrical activity from the necrotic, inactive ventricular tissue, allowing the contralateral ventricular forces to be predominant on the ECG. Patients who are poisoned by xenobiotics that cause vasoconstriction, such as cocaine (Chap. 74), other α-adrenergic agonists, or the ergot alkaloids, are particularly prone to develop focal myocardial ischemia and infarction. The specific electrocardiographic manifestations help to identify the region of injury and may, to some extent, be correlated with an arterial flow pattern: inferior (leads II, III, aVF; right coronary artery), anterior (leads I, aVL; left anterior descending artery), or lateral (leads aVL, V5–6; circumflex branch).