Download Jet Fuel Toxicology by Mark L Witten PDF

By Mark L Witten

ISBN-10: 1420080210

ISBN-13: 9781420080216

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Extra resources for Jet Fuel Toxicology

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Toxicol. Environ. Health, 2001b, Part A, 64(5): 385–415. , A reevaluation of the threshold exposure level of inhaled JP-8 in mice. Toxicol. , 2006, 31(3): 219–228. , JP-8 jet fuel exposure induces high levels of IL-10 and PGE2 secretion and is correlated with loss of immune function. Toxicol. Indus. Health, 2007, 23: 223–230. , Dermal exposure to jet fuel suppresses delayed type hypersensitivity: A critical role for aromatic hydrocarbons. Toxicol. , 2007; 100: 415–422. , In vivo comparison of epithelial responses for S-8 versus JP-8 jet fuels below permissible exposure limit.

Significant decreases were detected in expiratory lung resistance and total lung compliance of the 352-mg/m3 38 Jet Fuel Toxicology group, for which no clear concentration-dependent alterations could be determined. No significant changes in respiratory permeability were exhibited, indicating that there was no loss of epithelial barrier integrity following S-8 exposure. However, morphological examination and morphometric analysis of distal lung tissue, using transmission electron microscopy (TEM), revealed cellular damage in alveolar type II epithelial cells, with significant increases in volume density of lamellar bodies/vacuoles at 352 and 616 S-8 mg/m3.

Moreover, lung tissues from rats exposed to occupational levels of JP-8 by nasal aerosol also showed dysregulated expression of TNF-α, IL-8, and IL-6, thus confirming the in vitro data. The poly(ADP-ribosyl) ation of PARP-1, a coactivator of NF-κB, was coincident with the prolonged activation of NF-κB during JP-8 treatment. These results demonstrated that expression of JP-8-induced inflammatory cytokine genes in AEII cells was mediated by NF-κB and PARP-1. Proteomic and Genomic Changes Proteomic analysis of lungs in male Swiss-Webster mice exposed for 1 hour/day for 7 days to JP-8 at concentrations of 1000 and 2500 mg/m3 showed significant 34 Jet Fuel Toxicology quantitative and qualitative changes in tissue cytosol proteins [6, 16].

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