By Michael Aschner, Lucio G. Costa
ISBN-10: 0849317940
ISBN-13: 9780849317941
Providing the newest learn in glial mobilephone functionality gleaned from new options in imaging and molecular biology, The function of Glia in Neurotoxicity, moment variation covers a number of elements of glial cells, together with morphology, body structure, pharmacology, biochemistry, pathology, and their involvement within the pathophysiology of neurological illnesses. The booklet is established to ascertain the interactions among glial cells and neurons in the course of improvement, maturity, and senescence, via particular examples of without delay mediated glial neurotoxicity. The ebook additionally covers miscellaneous themes in glial physiology/biochemistry akin to signaling and edema. The booklet comprises assurance of advances in our wisdom and realizing of glial body structure and biochemistry. detect what is new within the moment Edition:Neuronal-glia metabolic interactionsNeuronal-glia interactions (glutamate homeostasis)Zinc transporters in gliaEnergy deprivation/mitochondrial disorder - specified astrocyte susceptibilitiesAstrocytes and MPTP neurotoxicityAstroglia and nutrients toxinsCurrent figuring out of the significance of glia has prompted a increase in released info. but whereas a few of the released textbooks are multifaceted and multidisciplinary, none comprises the position of glia in neurotoxicity. Written by way of leaders within the box of glial examine, this article fills this lacking hole within the literature. Broader in scope than the 1st version, together with contributions from across the world recognized researchers, this can be nonetheless the one e-book devoted to exploring the function of glial cells in mediating neurotoxicology.FeaturesSummarizes the most recent learn in glial phone functionality gleaned from new concepts in imaging and molecular biologyContains tables and figures that provide you with quickly and simple entry to express dataIncludes a modern precis of literature that places details valuable for provide submissions at your fingertipsFeatures new chapters protecting metabolic interactions, glutamate homeostasis, transporters, power deprivation/mitochondrial disorder, astrocytes, and nutrients pollution Explores the position of glial cells in mediating neurotoxicity and comprises info on particular results of many compounds
Read or Download The Role of Glia in Neurotoxicity, Second Edition PDF
Best toxicology books
In Vitro Methods in Pharmaceutical Research
In Vitro tools in Pharmaceutical learn offers a complete advisor to laboratory concepts for comparing in vitro organ toxicity utilizing mobile types. step by step sensible easy methods to practice and interpret assays for drug metabolism and toxicity evaluate are supplied, in addition to a comparability of other innovations to be had.
Casarett and Doull's toxicology
The main depended on all-in-one assessment of the biomedical and environmental facets of toxicology--NOW extra whole, updated, and in complete colorA Doody's middle name for 2015! NEW to the 8th version FULL-COLOR layout to permit for a clearer interpretationof the fundamental elements of toxicology featured in the course of the textual content accelerated tables, illustrations, and different visuals areupdated with cutting-edge criteria that makes thisedition much more present and appropriate DVD with photograph financial institution good points all tables and illustrations from the textual content in presentation-ready structure NEW CHAPTERS contain "Toxic results of Calories"and "Toxic results of Nanoparticles"The world's prime and such a lot authoritative textbook on poisons has extra to supply students,toxicologists, and pharmacologists than ever sooner than.
This ebook describes in attention-grabbing element the diversity of experiments subsidized through the U. S. executive within which human topics have been uncovered to radiation, usually with out their wisdom or consent. according to a evaluate of thousands of heretofore unavailable or labeled files, this record tells a gripping tale of the elaborate dating among technology and the nation.
The IACUC administrator's guide to animal program management
The IACUC Administrator’s advisor to Animal application administration helps IACUC administrators who assist with constructing, handling, and overseeing a application of animal care and animal use. It offers many recommendations and probabilities for particular operational practices (e. g. , how you can construct a well-functioning IACUC, what a sensible protocol template appears like) to fulfill regulatory standards.
- Lipophilicity in Drug Action and Toxicology
- Botulinum Neurotoxin for Head and Neck Disorders
- Toxins in Food
- The elements of murder. A history of poison
- The Dose Makes the Poison: A Plain-Language Guide to Toxicology, 3rd Edition
Additional resources for The Role of Glia in Neurotoxicity, Second Edition
Sample text
Nicotinic receptor-induced apoptotic cell death of hippocampal progenitor cells, J. , 8, 6871, 1998. 23. , Autism: a novel form of mercury poisoning, Med. Hypotheses, 56, 462, 2001. 24. , A stochastic model of temporally regulated generation of oligodendrocytes in cell culture, Math. , 159, 47, 1999. 25. Brookes, N. , Inhibition of amino acid transport and protein synthesis by HgCl2 and methylmercury in astrocytes: selectivity and reversibility, J. , 53, 1228–1237, 1989. 26. , Methylmercury developmental neurotoxicity: a comparison of effects in humans and animals, Neurotoxicol.
H. , 18, 462, 1997. 149. , The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells, Neurotoxicology, 20, 793–804, 1999. 150. , Effect of prenatal ethanol exposure on neuronal migration, neurogenesis and brain myelination in the mice brain, Clin. , 19, 21, 2000. © 2005 by CRC Press 24 THE ROLE OF GLIA IN NEUROTOXICITY 151. , Methylmercury induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists, Neurotoxicology, 17, 37–46, 1996.
126. , Environmental factors associated with a spectrum of neurodevelopmental deficits, Ment. Retard. Dev. Disabil. Res. , 8, 188, 2002. 127. , Effect of prenatal exposure to ethanol on the development of cerebral cortex: I. Neuronal generation, Alcohol. Clin. Exp. , 12, 440–449, 1988. 128. , Effect of prenatal exposure to ethanol on neocortical development: II. Cell proliferation in the ventricular and subventricular zones of the rat, J. Comp. , 278, 326–338, 1989. © 2005 by CRC Press NEURAL PRECURSOR CELLS AND TOXICANT ACTION 23 129.