By Gary W Miller
ISBN-10: 0124172172
ISBN-13: 9780124172173
The Exposome: A Primer is the 1st ebook devoted to exposomics, detailing the aim and scope of this rising box of research, its sensible purposes and the way it enhances a vast diversity of disciplines. Genetic reasons account for as much as a 3rd of all advanced ailments. (As genomic techniques increase, this can be more likely to rise.) Environmental components additionally effect human illness yet, in contrast to with genetics, there isn't any general or systematic option to degree the impression of environmental exposures. The exposome is an rising idea that hopes to deal with this, measuring the results of life-long environmental exposures on healthiness and the way those exposures can impression ailment.
This systematic advent considers subject matters of dealing with and integrating exposome info (including maps, versions, computation, and structures biology), "-omics"-based applied sciences, and extra. either scholars and scientists in disciplines together with toxicology, environmental future health, epidemiology, and public well-being will take advantage of this rigorous but readable overview.
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Additional info for The Exposome. A Primer
Example text
If cost was not an issue would you want to have your genome sequenced? Is there any information you would rather not know? 26 The Exposome How do we protect this type of very invasive and private information? Should our health care and insurance providers have access to it? How does having access to such information change one’s behavior? For example, if you know that you had a twofold increased risk of having a heart attack would you alter your behavior? FURTHER READING Dolinoy DC, Huang D, Jirtle RL.
2 Populations to molecules. Exposome-related data will come from a broad range of sources, including population studies, personal environmental and biological monitoring, and from laboratory studies of animals, cells, and molecules. The Exposome in Environmental Health Sciences and Related Disciplines 41 occupation is removed from the definition of environment, one of the biggest sources of potential exposures is being arbitrarily excluded. Part of this classification structure is also due to the organizational structure of the agencies that fund this research.
While most are familiar with the quantitative structure activity relationships (QSAR) used in drug development, a similar approach can be used in toxicology to model potential toxic interactions. The US Environmental Protection Agency (EPA) has established a Computational Toxicology Center to develop and apply computational tools to aid with the prediction of toxicity as it relates to regulatory decision-making. The fact that only a small fraction of chemicals introduced into our environment have undergone toxicological testing highlights the need for faster and less expensive means of assessing toxicity.