By Wanda M. Haschek
ISBN-10: 0123302153
ISBN-13: 9780123302151
A finished realizing of toxicologic pathology is vital for these in undefined, academia, and govt who make judgements about the security and efficacy of gear and chemical compounds. Toxicologic pathology is predicated seriously at the fields of either toxicology and pathology, that are good lined separately in quite a few texts and references; despite the fact that, there are few texts that tackle the sector of toxicologic pathology. The guide of Toxicologic Pathology fills this void and is therefore crucial for all health and wellbeing execs inside of or interacting with the sphere of toxicologic pathology.
This two-volume set offers the reader with a unmarried reference for toxicologic pathology. In quantity I, the publication covers toxicologic pathology in its simple features, together with its definition, the elemental biochemical and morphologic mechanisms underlying the self-discipline, the fundamental perform of toxicologic pathology (including exact innovations) and concerns necessary to the knowledge of toxicologic pathology comparable to possibility evaluation, experimental layout, and statistical research. subsequent, the booklet strikes to precise matters affecting the "practice" toxicologic pathology, together with matters equivalent to wisdom administration, regulatory affairs and writing pathology stories. ultimately, Volume I closes with a number of chapters that care for particular periods of environmental toxicants equivalent to endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a completely standardized structures demeanour, addressing the fundamental constitution and serve as of a selected organ process, its reaction to poisonous damage, mechanisms of damage and techniques of overview of such damage.
Key Features
* effortless to discover, up to date reference information
* picture and photographic plates
* present scorching issues and expected adjustments in toxicologic pathology
* Standardized bankruptcy format
* subject matters which are addressed in either a wide and deep demeanour, leading to a stand on my own textual content
* extra insurance of vital environmental toxicants
* Chapters authored by means of the world over famous specialists and peer-reviewed
Read Online or Download Haschek and Rousseaux's Handbook of Toxicologic Pathology, Second Edition PDF
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Extra resources for Haschek and Rousseaux's Handbook of Toxicologic Pathology, Second Edition
Sample text
Summary Chapter 7: Nomenclature I. Introduction II. Terminology Issues III. Suggested Practices IV. Summary PART B: The Practice of Toxicologic Pathology Chapter 8: Basic Techniques I. Introduction II. Factors Influencing the Evaluation of Altered Morphology III. Summary Chapter 9: Managing Pitfalls in Toxicologic Pathology I. Introduction II. Study Design III. Necropsy IV. Histology V. Computer Systems VI. Peer Review VII. Conclusions Chapter 10: Special Techniques in Toxicologic Pathology I. Introduction II.
Genetically Engineered Mice Can Be Used for in Vivo Genetic Toxicity Testing III. Genetically Engineered Mice Can Be Used to Study Mechanisms of Toxicity in Vivo IV. Genetically Modified Mice Can Be Used for Special or Customized Toxicity Testing V. Genetically Engineered Mice Can Be Useful for Short-Term Carcinogenicity Testing VI. Caveats Apply to the Use of Genetically Engineered Mice in Research VII. New Gene-Altering Technologies Will Produce More Sophisticated Mouse Models Chapter 14: Pathology Issues in the Design of Toxicology Studies I.
Mechanisms of Disease and Classification of Neurotoxic Diseases IV. Testing for Neurotoxicity V. Conclusions Chapter 38: The Eye I. Introduction II. Development of the Eye III. Cornea IV. Lens V. Retina and Retinal Pigment Epithelium VI. Toxicologic, Clinical, and Pathologic Evaluation VII. Ocular Toxicity Testing VIII. Conclusions Chapter 39: Immune System I. Introduction II. Structure and Function of the Immune System III. Mechanisms of Immune Toxicity IV. Response of Lymphoid Tissue to Toxic Injury V.